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OwnerRobert D. Kross, Cleva Villanuevainventors
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A composition and method are described for suppressing or preventing fibrous adhesion formation using a multicomponent aqueous oxychlorine composition. Fibrous adhesions typically form during healing of tissue, for example following a surgical procedure. A multicomponent oxychlorine composition is provided for irrigating the tissue which minimizes post-surgical adhesion formation, the composition containing both chlorine dioxide and chlorite ion, and a complexion thereof. The chlorine dioxide level generally is in an effective range of ClO2 concentration from about 10 ppm to a maximum of about 110 ppm. In a preferred embodiment, a physiological composition is provided in a thickened form to increase retention in the area being treated. The composition is preferably based on a standard saline solution converted to the oxychlorine composition just prior to use by sequential addition of aqueous concentrates of a chlorite salt, a hypochlorite salt combined with a physiological buffer-producing salt of a multibasic acid, and an acidifying agent, optionally including a thickening agent.
A composition prepared on-site for the suppression or reduction in the likelihood of formation of fibrous adhesions in tissue of a mammal comprising:
A method for suppressing or reducing the likelihood of the development of fibrous adhesions in tissue of a mammal comprising treating the tissue with an effective amount of a composition prepared on-site comprising a multiple oxychlorine species-containing buffered, isotonic composition, further comprising providing an isotonic saline solution and sequentially injecting into the isotonic saline solution aqueous concentrates of 1) a chlorite salt, 2) a hypochlorite salt combined with a physiological buffer-producinq salt of a multibasic acid, and 3) an acidifying agent.
A method for suppressing or reducing the likelihood of the development of fibrous adhesions resulting from a surgical procedure performed on a surgical site comprising treating the surgical site with an effective amount of a composition prepared on site comprising a multiple oxychlorine species-buffered, isotonic composition further comprising, immediately prior to use of the composition, making the composition by providing an isotonic saline solution and sequentially injecting into the isotonic saline solution aqueous concentrates of 1)a chlorite salt, 2) a hypochlorite salt combined with a physiological buffer-producing salt of a multibasic acid, and 3) an acidifying agent, to provide a composition having a molar ratio of formed chlorine dioxide to residual chlorite ion equal to or less than about 3.5to 1, the level of chlorine dioxide being in the range from about 10parts per million (ppm) to about 110 ppm.
Dependencies are inferred from the claim text.