Colonic purgative composition with soluble binding agent
AssigneeSalix Pharmaceuticals, Inc.
InventorsStephen Skiendzielewski, Martin Rose, Ngoc Do
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Abstract
This invention relates to novel colonic purgative compositions in a solid dosage form, comprising at least one purgative and at least one soluble, or soluble, nonfermentable binder, such as polyethylene glycol. Further, this invention relates to methods of using the colonic purgative compositions. The present compositions and methods are designed to improve patient tolerance and compliance, while at the same time improving the quality of bowel cleansing. The formulations and methods of this invention are particularly useful to cleanse the bowel prior to diagnostic and surgical procedures and can also be employed in lower dosages as a laxative to promote elimination and/or to relieve constipation.
Claims22
A method of making a solid dosage colonic purgative formulation in a tablet form, comprising:
- heating a formulation comprising sodium phosphate and polyethylene glycol 8000 to a temperature not exceeding the melting point of the polyethylene glycol;
- and
- compressing the formulation into a tablet.
A method of making a solid dosage colonic purgative tablet formulation, comprising:
- heating a formulation comprising 60%-90% sodium phosphate and 5% to 20% polyethylene glycol 8000 to a temperature not exceeding the melting point of polyethylene glycol;
- allowing the formulation to cool below 30° C.;
- and
- compressing the formulation into tablets.
Dependencies are inferred from the claim text.