Dosage forms for tamper prone therapeutic agents
AssigneeAtlantic Pharmaceuticals, Inc.
InventorsAtul J. Shukla, Anthony Edward Soscia, Yingxu Peng, Yichun Sun, James R. Johnson
Life of this patent
Estimating the term…
Abstract
A dosage form from which a burst release of a drug contained within a tampered dosage form is reduced or retarded by the presence in or on the dosage form of a TPTA (Tamper Prone Therapeutic Agent) trap. If the dosage form has not been tampered with, the TPTA trap does not significantly interfere with the rate of release of the drug from the dosage form. However, if the dosage form has been physically tampered with, the TPTA trap reduces or retards burst release of the drug from the dosage form.
Claims11
A method for reducing or retarding burst release of a drug from a dosage form that has been tampered with comprising providing a dosage form comprising a drug and a TPTA (Tamper Prone Therapeutic Agent) trap, wherein the dosage form comprises a multiplicity of subunits and/or layers, and wherein the drug and the TPTA trap are maintained separately in different subunits or layers of the dosage form, and wherein if the TPTA trap comprises a gelling agent, the TPTA trap comprises a TPTA trap activator and, either (a) the gelling agent and the TPTA trap activator are sequestered from each other within the dosage form or (b) the gelling agent and the TPTA trap activator are not sequestered from each other and the gelling agent is in a gelled state within the dosage form.
Dependencies are inferred from the claim text.