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US 8,506,987 B2Granted
Ocular implant made by a double extrusion process
AssigneeAllergan, Inc.
InventorsJane-Guo Shiah, Rahul Bhagat, Wendy M. Blanda, Thierry Nivaggioli, Lin Peng, David Chou, David A. Weber
Life of this patent
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Abstract
The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.
Claims13
A method for treating a medical condition of the eye comprising implanting into an ocular region of the eye a bioerodible implant and delivering a therapeutic amount of an active agent to the ocular region, wherein
- a) the bioerodible implant is a double extruded rod comprising an active agent homogeneously dispersed within a biodegradable polymer matrix;
- wherein
- b) the biodegradable polymer matrix comprises a mixture of hydrophilic ended poly(D,L-lactide-co-glycolide) (PLGA) and hydrophobic ended poly(D,L-lactide-co-glycolide) (PLGA);
- wherein the hydrophilic- and hydrophobic-end PLGAs are milled prior to extrusion with the active agent;
- wherein
- c) the bioerodible implant is sized for implantation in an ocular region;
- and wherein
- d) the medical condition of the eye is selected from the group consisting of uveitis, macular edema, macular degeneration, retinal detachment, ocular tumors, fungal infections, viral infections, multifocal choroiditis, diabetic retinopathy, proliferative vitreoretinopathy (PVR), sympathetic ophthalmia, Vogt Koyanagi-Harada (VKH) syndrome, histoplasmosis, uveal diffusion, and vascular occlusion.
5 more elements
Dependencies are inferred from the claim text.