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US 8,506,982 B2Granted
Development of a human colloidal bone graft material
AssigneeOsteosphere, LLC
InventorsAlamelu Sundaresan, Mark S. F. Clarke, Mark Brinker
Life of this patent
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Abstract
The present disclosure provides colloidal bone graft compositions comprising a plurality of mineralized three-dimensional bone constructs, a polymerizable biocompatible matrix, an osteoblast differentiation agent, and at least one osteoblast mineralization agent. The colloidal bone graft compositions of the disclosure are used to perform bone grafts in human or animal patients.
Claims9
A colloidal bone graft composition comprising:
- (a) a plurality of mineralized three-dimensional bone constructs each comprising a spheroid of between about 200 μm and about 4 mm in diameter, the spheroid having an outer layer surrounding an inner core, wherein said outer layer comprises osteoclasts, wherein said inner layer comprises osteoblasts, osteocytes, or both osteoblasts and osteocytes embedded within a crystalline matrix, and wherein said crystalline matrix comprises calcium, phosphates, and carbonates;
- (b) a polymerizable biocompatible matrix;
- (c) an osteoblast differentiation agent;
- and
- (d) at least one osteoblast mineralization agent.
2 more elements
Dependencies are inferred from the claim text.