Injectable anticancer composition for local administration containing hydroxychloroquine
OwnerOh-Young Yeoinventor
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Abstract
The present invention relates to an injectable anticancer composition for local administration comprising hydroxychloroquine. The anticancer composition shows an IC50 value against sarcoma-180 cells, which is about 10 times lower than cisplatin, as determined by the MTT assay in vitro, suggesting that the anticancer composition has an excellent cytotoxic effect. Also, the anticancer composition shows dose-dependent effects against solid cancer induced by sarcoma-80 cells in vivo. In addition, the anticancer composition has the effect of extending the life expectancy of patients having ascites cancer induced by sarcoma-80 cells.
Claims11
An injectable anticancer composition for local administration comprising hydroxychloroquine or its salt, wherein the content of hydroxychloroquine in the composition is 20-25% (w/v).
A method for treating cancer, comprising:
- preparing an injectable anticancer composition for local administration, the composition comprising 20-25% (w/v) hydroxychloroquine or its salt;
- and
- injecting the composition directly into cancer cells.
Dependencies are inferred from the claim text.