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US 8,506,970 B2Granted
Dose and localization of botulinum toxins in skin and muscle
AssigneeDt Scimed, LLC
InventorL. Andrew Koman
Life of this patent
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Abstract
A novel dosing regimen for the administration of botulinum toxin based on the pattern, quantity, and location of neuromuscular junctions in the target tissue. Because the number of neuromuscular junctions in a target tissue remains generally stable throughout life and because the pharmacological effect of botulinum toxin is localized at the neuromuscular junction, dosing efficacy is unaffected by muscle mass, age of the patient, or body weight.
Claims8
A method for dosing botulinum toxin in a living human muscle of a patient comprising the steps of:
- a) determining the mass of a target muscle relative to the mass of a lateral gastrocnemius muscle of the patient;
- b) determining the distribution and location of neuromuscular junctions (NMJ) in said target muscle as mediated by ultrasound localization;
- and,
- c) injecting a dosing regimen comprising a plurality of volumetrically optimized doses of botulinum toxin within a distance of about 3.0 cm of said neuromuscular junctions relative to the quantity of said neuromuscular junctions in said target muscle and the ratio of said mass of said lateral gastrocnemius muscle with the mass of said target muscle with the number of doses being dictated by the length and width of the target muscle.
1 more element
Dependencies are inferred from the claim text.