Functional influenza virus like particles (VLPs)
AssigneeNovavax, Inc.
InventorsGale Smith, Rick Bright, Peter M. Pushko, Jinyou Zhang, Kutub Mahmood
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Abstract
The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
Claims19
A method of inducing substantial immunity to an influenza virus infection in a human susceptible to influenza, comprising administering to said human at least one effective dose of a vaccine, said vaccine comprising an influenza VLP, wherein said VLP comprises influenza M1, HA and NA proteins and wherein said M1 protein is from an avian influenza virus, and wherein said M1 protein is from a different strain of influenza virus than said influenza HA protein and said influenza NA protein.
Dependencies are inferred from the claim text.