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US 8,506,964 B2Granted
Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis
AssigneeCardioVax, LLC
InventorsJan Nilsson, Goran K. Hansson, Jan Holmgren
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Abstract
A fusion protein comprising an antigenic fragment of apoB-100 and a suitable carrier and related compositions methods and systems.
Claims13
A fusion protein comprising
- (a) an antigenic fragment of apoB-100 protein, wherein the fragment is P2, P11, P25, P32, P45, P74, P102, P129, P143, P148, P154, P162, P210, P219, or P240 ;
- and
- (b) a protein carrier comprising subunit B of cholera toxin,
- wherein the antigenic fragment and the protein carrier are comprised in the fusion protein in a 1:1 fragment:carrier molar ratio;
- and
- wherein the fusion protein is capable of inducing antigen specific regulatory T cells, the antigen specific regulatory T cells being specific for the antigenic fragment of apoB-100.
3 more elements
A method to produce a fusion protein, the method comprising
- attaching an antigenic fragment of apoB-100, wherein the fragment is P2, P11, P25, P32, P45, P74, P102, P129, P143, P148, P154, P162, P210, P219, or P240 with a suitable protein carrier comprising subunit B of cholera toxin in a 1:1 fragment:carrier molar ratio to provide a fusion protein capable of inducing antigen specific regulatory T cells,
- the antigen specific regulatory T cells being specific for the fragment of apoB-100.
Dependencies are inferred from the claim text.