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US 8,506,958 B2Granted
Methods for treating TWEAK-related conditions
AssigneeBiogen Idec MA Inc.
InventorsLinda C. Burkly, Aniela Jakubowski, Timothy Zheng, Kyungmin Hahm
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AssigneeBiogen Idec MA Inc.
InventorsLinda C. Burkly, Aniela Jakubowski, Timothy Zheng, Kyungmin Hahm
Estimating the term…
The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
A method for treating non-inflammatory dilated cardiomyopathy, in a human subject comprising the step of administering to the subject a therapeutically effective amount of an antibody that binds human TWEAK (an anti-TWEAK antibody) or antigen-binding fragment thereof.
Dependencies are inferred from the claim text.