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US 8,506,954 B2Granted
Tumor vaccination in combination with hematopoietic cell transplantation for cancer therapy
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsSamuel Strober, Alexander Filatenkov
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Abstract
In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments, the method involves autologous tumor cell vaccination prior to autologous hematopoietic and immune cell transplantation. In another aspect, the present invention provides a method of purifying tumor cells from a subject in preparation for vaccination.
Claims12
A method for treating cancer of a subject comprising:
- (a) obtaining purified solid tumor cells from the subject wherein the solid tumor cells are selected from the group consisting of colorectal tumor, lung tumor, breast tumor, pancreatic tumor, liver tumor, prostate tumor, and ovarian tumor;
- (b) vaccinating the subject with cancer with said purified solid tumor cells that have been irradiated and formulated in combination with an adjuvant;
- (c) collecting immune and hematopoietic cells from the vaccinated subject;
- (d) irradiating said subject to myeloablative total body irradiation;
- and
- (e) injecting the collected immune and hematopoietic cells from the subject intravenously into said subject, without ex vivo T cell expansion or treatment with cytokines.
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Dependencies are inferred from the claim text.