Methods for modulating inflammatory and/or immune responses
AssigneeStemnion, Inc.
InventorsVivienne S. Marshall, Richard A. Banas, Catherine J. Trumpower
Life of this patent
Estimating the term…
Abstract
The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents.
Claims4
A method for down-regulating the immune response a subject's peripheral blood mononuclear cells (PBMCs) exhibit when they are exposed to a non-self antigen present on a transplanted tissue, the method comprising the step of contacting the subject's PBMCs with a purified population of CD117-negative Amnion-derived Multipotent Progenitor (AMP) cells subsequent to the exposure of the subject's PBMCs to the non-self antigen present on a transplanted tissue such that the AMP cells down-regulate the immune response exhibited by the PBMCs to the non-self antigen present on a transplanted tissue.
Dependencies are inferred from the claim text.