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US 8,506,933 B2Granted
Methods of detecting a neurological condition via analysis of circulating phagocytes
AssigneeMSDx, Inc.
InventorRamesh C. Nayak
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Abstract
The present invention features methods of monitoring or detecting a neurological or inflammatory condition in a patient. The method comprises (1) obtaining from the patient a fluid sample from outside of a brain tissue of the patient, wherein the fluid sample contains a circulating phagocyte, and (2) detecting for one or more biomarkers (e.g., a panel of biomarkers) inside the phagocyte, wherein the biomarker is associated with the respective neurological or inflammatory condition.
Claims1
A method of detecting multiple sclerosis in a patient, the method comprises:
- (a) obtaining from the patient a fluid sample from outside of a brain tissue of the patient, the fluid sample comprises a blood sample or a cerebrospinal fluid sample, the fluid sample contains a circulating phagocyte;
- and
- (b) detecting a multiple sclerosis-associated biomarker in the phagocyte, the biomarker is a neural-specific biomarker comprising Tau, a fragment of Tau, phosphorylated Tau, hippocalcin-1, or 14-3-3 protein;
- wherein detecting the biomarker in the phagocyte obtained from the fluid sample at a level higher than that of a control is indicative that the patient has multiple sclerosis.
1 more element
Dependencies are inferred from the claim text.