Compounds having affinity for amyloid
AssigneeNihon Medi-Physics Co., Ltd.
InventorsShigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
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AssigneeNihon Medi-Physics Co., Ltd.
InventorsShigeyuki Tanifuji, Daisaku Nakamura, Shinya Takasaki, Yuki Okumura
Estimating the term…
The present invention provides a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagencity. Provided is a compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represents a carbon or nitrogen; R1 is a halogen substituent; R2 is a halogen substituent; and m is an integer of 0 to 2, provided that at least one of R1 and R2 is a radioactive halogen substituent, at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4 as well as a low-toxic diagnostic agent comprising a compound represented by the preceding formula or a salt thereof.
A compound represented by the following formula (3), or a salt thereof:
A compound represented by the following formula (4) or a salt thereof:
A diagnostic agent for Alzheimer's disease, which comprises a compound represented by the following formula (3), or a salt thereof:
Dependencies are inferred from the claim text.