Methods and compounds for targeting tissues
AssigneeThe Regents of the University of California
InventorsKatherine Ferrara, Hua Zhang, Jiro Kusunose
Life of this patent
Estimating the term…
Abstract
The present invention relates to peptides which home to cells, e.g. heart cells, with high selectivity and which can be useful in the form of compositions. Such compositions can be used, e.g., for selectively targeting a systemically administered therapeutic agent or imaging agent to a cell or tissue in a subject. The present invention further relates to methods of using the compositions for imaging, e.g. PET imaging, and targeting cells, e.g. for delivering a therapeutic agent to one or more target cells in a subject.
Claims41
A composition for delivering a compound to a cell, comprising:
- at least one peptide comprising a free C-terminus and a linked N-terminus and a plurality of amino acid residues, said peptide comprising a C-terminal arginine residue positioned at said free C-terminus of said peptide, wherein said peptide targets said composition to said cell;
- a particle for carrying said compound, wherein said particle comprises at least one lipid molecule and a brush layer comprising 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (‘DSPE-PEG2000);
- and
- a linking molecule, wherein said linking molecule links said at least one peptide at said linked N-terminus to said particle.
Dependencies are inferred from the claim text.