Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging
AssigneeWashington University
InventorsRobert H. Mach, Zhude Tu
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Abstract
Pegylated fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labeled with a positron-emitting radioisotope such as 18F, can be used as radiotracers for medical imaging such as imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labeled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.
Claims20
A radiolabeled pegylated fluoroalkoxybenzamide compound or salt thereof of structure
- wherein m is an integer from 2 to 5, n is an integer from 1 to 10, and X1 and X2 are each independently selected from the group consisting of H, a halogen selected from the group consisting of I, Br, Cl and F, a C1-4 alkoxy, a C1-4 alkyl, a C1-4 fluoroalkyl, a C1-4 fluoroalkoxy, CF3, OCF3, SCH3, SCF3, and NH2.
A radiolabeled pegylated fluoroalkoxybenzamide compound or salt thereof of structure
- wherein m is an integer from 2 to 5, n is an integer from 1 to about 10, and X1 is selected from the group consisting of H, a halogen selected from the group consisting of I, Br, Cl and F, a C1-4 alkoxy, a C1-4 alkyl, a C1-4 fluoroalkyl, a C1-4 fluoroalkoxy, CF3, OCF3, SCH3, SCF3, and NH2 and X2 is selected from the group consisting of 76Br, 123I and 124I.
Dependencies are inferred from the claim text.