[18F]-furanosylpurine derivatives and uses thereof
AssigneeUniversity of Southern California
InventorsPeter S. Conti, Mian M. Alauddin, John D. Fissekis
Life of this patent
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Abstract
2′-Deoxy-2′-[18F]-labeled and 3′-deoxy-3′-[18F]-labeled purine nucleoside analogs such as [18F]-FAA and [18F]-FXA have been found to have desirable properties for use as imaging agents. The analogs are particularly useful for in vivo imaging of biological material including organ tissues (e.g., heart, liver, brain and kidneys) and tumors. Methods for the preparation of the [18F]-FAA and [18F]-FXA are also provided.
Claims18
A composition for in vivo imaging of a biological material, comprising:
- an imaging agent in dosage unit form, wherein the unit dose of the imaging agent comprises a sufficient amount for in vivo diagnostic imaging of a 2′-deoxy-2′-[18F]-labeled or a 3′-deoxy-3′-[18F]-labeled purine nucleoside analog for being detected in vivo;
- and
- a physiologically acceptable carrier or adjuvant.
An in vivo method for imaging a biological material in a subject, comprising:
- administering to said subject a sufficient amount of a composition comprising a 2′-deoxy-2′-[18F]-labeled or a 3′-deoxy-3′-[18F]-labeled labeled purine nucleoside analog to provide an imagable concentration of said analog in said biological material;
- and
- detecting emissions from said radioactive fluorine of said analog, thereby forming an image of said biological material.
A method for imaging a tumor in a patient, the method comprising:
- administering to a patient an composition comprising [18F]-FAA in an amount sufficient to provide an imagable concentration of said [18F]-FAA;
- and
- detecting emissions from said radioactive fluorine of said [18F]-FAA, thereby forming an image of said tumor.
Dependencies are inferred from the claim text.