Eyelid margin wipes comprising chemical means for temperature adjustment

An eyelid margin wipe for treatment of disorders of an eyelid or eyelid margin comprising:

• at least two components adapted to change a temperature of the wipe from an ambient temperature upon reaction with each other to an elevated temperature range of from about 40° C. to about 55° C.;
• a water-impermeable container that prevents the at least two components from coming into contact with a closed eye when in use;
• a seal for keeping the at least two components separate until temperature change is initiated, wherein the elevated temperature range is reached within 2 minutes after the temperature change is initiated and is maintained for at least 5 minutes without causing damage to a delicate eye region;
• and at least one agent selected from the group consisting of cleansing agents and surfactant agents, wherein the wipe has a size of one human eye region.