Sensors and sensing for monitoring neuromuscular blockade
OwnerTerence Gilhulyinventor
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Abstract
Improved sensors and sensing methods for detection of Neuromuscular Blockade (NMB), for example to improve monitoring generally, as well as facilitate automated NMB drug administration. The methods, systems, devices, etc., herein can increase the quantity and quality of data available. The methods, etc., include translation between commonly available sensing types, use of partially saturated sensor measurements, use of a model of neurotransmitter storage and release and sophisticated use of more than one sensor simultaneously. These methods are aided by new sensors and methods of decreasing electrical noise. An implementation of the methods, systems, devices, etc., herein is automated drug delivery for NMB, whether through an advisor system or through with full computer control.
Claims24
A system for quantifying a neuromuscular response, the system comprising:
- (a) a stimulator configured to apply a first mode of stimulation to the patient, wherein the first mode of stimulation is Train Of Four (TOF);
- (b) one or more sensors configured to measure the patient's response to stimulation;
- and
- (c) a computer configured to:
- i. interpret the measured response to the first mode of stimulation as the measured response in terms of a second mode of stimulation when the measured response is not responsive to some or all of the stimulation from the first mode of stimulation, wherein the second mode of stimulation is one of Train of Three (TO3), Train of Two (TO2), and Single Twitch (ST);
- and
- ii. translate the measured response in terms of the second mode of stimulation into an output representative with respect to the first mode of stimulation with an equation.
A system for quantifying a neuromuscular response, the system comprising:
- (a) a stimulator configured to apply first and second modes of stimulation to the patient, wherein the first mode of stimulation is Train Of Four (TOF) and the second mode of stimulation is Post Tetanic Count (PTC);
- (b) one or more sensors configured to measure the patient's response to stimulation;
- and
- (c) a computer configured to:
- i. direct the stimulator to apply the second mode of stimulation when the measured response is not responsive to all of the stimulation from the first mode of stimulation;
- and
- ii. translate the measured response to the second mode of stimulation into an output representative with respect to the first mode of stimulation with an equation.
A system for quantifying a neuromuscular response, the system comprising:
- (a) a stimulator configured to apply first and second modes of stimulation to the patient, wherein the first mode of stimulation is Train Of Four (TOF) and the second mode of stimulation is one of Double Burst Stimulation (DBS) or Single Twitch (ST);
- (b) one or more sensors configured to measure the patient's response to stimulation;
- and
- (c) a computer configured to:
- i. direct the stimulator to apply the first mode of stimulation;
- ii. direct the stimulator to apply the second mode of stimulation;
- and
- iii. translate the measured response to the second mode of stimulation into an output representative with respect to the first mode of stimulation with an equation.
A system for quantifying a neuromuscular response, the system comprising:
- (a) a stimulator configured to apply first and second modes of stimulation to the patient, wherein the first mode of stimulation is Double Burst Stimulation (DBS) and the second mode of stimulation is Train Of Four (TOF);
- (b) one or more sensors configured to measure the patient's response to stimulation;
- and
- (c) a computer configured to:
- i. direct the stimulator to apply the first mode of stimulation;
- ii. direct the stimulator to apply the second mode of stimulation;
- and
- iii. translate the measured response to the second mode of stimulation into an output representative with respect to the first mode of stimulation with an equation.
A system for quantifying a neuromuscular response, the system comprising:
- (a) a stimulator configured to apply first and second modes of stimulation to the patient, wherein the first mode of stimulation is Single Twitch (ST) and the second mode of stimulation is Train Of Four (TOF);
- (b) one or more sensors configured to measure the patient's response to stimulation;
- and
- (c) a computer configured to:
- i. direct the stimulator to apply the first mode of stimulation;
- ii. direct the stimulator to apply the second mode of stimulation;
- and
- iii. translate the measured response to the second mode of stimulation into an output representative with respect to the first mode of stimulation with an equation.
A method for controlling the administration of a neuromuscular blockade based on a patient's neuromuscular response, the method comprising:
- (a) applying a first mode of stimulation to the patient, wherein the first mode of stimulation is Train Of Four (TOF);
- (b) measuring the response produced by the first mode of stimulation;
- (c) interpreting the measured response to the first mode of stimulation as the measured response in terms of a second mode of stimulation when the measured response is not responsive to some of the stimulation from the first mode of stimulation, wherein the second mode of stimulation is one of Train of Three (TO3), Train of Two (TO2), and Single Twitch (ST);
- (d) translating the measured response in terms of the second mode of stimulation into an output representative with respect to the first mode of stimulation with an equation;
- and
- (e) controlling the administration of the neuromuscular blockade via computer based on the measured response when the patient is responsive to all of the stimulation from the first mode of stimulation, and controlling the administration of the neuromuscular blockade based on the output representative with respect to the first mode of stimulation when the patient is not responsive to some or all of the stimulation from the first mode of stimulation.
Dependencies are inferred from the claim text.