Single particle QCL-based mid-IR spectroscopy system with analysis of scattering
OwnerMatthias Wagner, John Heanueinventors
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Abstract
This disclosure concerns a system with scattering analysis including a handling system that presents a single particle to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle. A mid-infrared detection facility detects the mid-infrared wavelength light scattered by the single particle, wherein a wavelength and angle analysis of the scattered mid-IR wavelength light is used to determine analyte-specific structural and concentration information.
Claims20
A system with scattering analysis, comprising:
- a handling system that presents a single particle, that has not been chemically conditioned for analysis, to at least one quantum cascade laser (QCL) source;
- the at least one QCL laser source configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle;
- and
- a mid-infrared detection facility that detects a mid-infrared wavelength light scattered by the single particle,
- wherein an analysis of intensity versus at least one of wavelength and angle of the scattered mid-infrared wavelength light is used to determine analyte-specific structural and concentration information.
A system with scattering analysis, comprising:
- a handling system that presents a single particle to at least one quantum cascade laser (QCL) source;
- the at least one QCL source configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle;
- and
- a mid-infrared detection facility that detects a mid-infrared wavelength light scattered by the single particle,
- wherein an analysis of intensity versus at least one of wavelength and angle of the scattered mid-infrared wavelength light is used to determine analyte-specific structural and concentration information, and
- wherein the at least one QCL source is configured to deliver light to a particle in a volume of a microfluidic handling system.
A system with scattering analysis, comprising:
- a handling system that presents a single cell to at least one quantum cascade laser (QCL) source;
- the at least one QCL source configured to deliver light to the single cell in order to induce resonant mid-infrared absorption in the particle or an analyte within the cell;
- and
- a mid-infrared detection facility that detects a mid-infrared wavelength light scattered by the single cell,
- wherein an analysis of intensity versus at least one of wavelength and angle of the scattered mid-infrared wavelength light is used to determine analyte-specific structural and concentration information, and
- wherein the cell remains viable after the analysis.
Dependencies are inferred from the claim text.