Compositions comprising cardiac stem cells overexpressing specific microRNAs and methods of their use in repairing damaged myocardium
AssigneeNew York Medical College
InventorsToru Hosoda, Piero Anversa, Annarosa Leri, Jan Kajstura
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Abstract
The invention provides compositions comprising modified stem cells containing a transgene that affects the expression of at least one gene that inhibits or promotes cardiomyogenesis. In particular, the invention discloses compositions comprising cardiac stem cells, wherein said cardiac stem cells comprise a transgene encoding a microRNA. The compositions of the invention find use in the treatment of cardiovascular disorders, such as myocardial infarction. Methods of repairing damaged myocardium in a subject using the modified stem cells are also disclosed.
Claims19
A method for regenerating damaged myocardium in a subject in need thereof comprising:
- (a) administering cardiac stem cells to an area of damaged myocardium in the subject, wherein the cardiac stem cells differentiate into myocytes, smooth muscle cells, and endothelial cells after their administration, thereby regenerating the damaged myocardium;
- and
- (b) administering a transgene encoding miR-499 to the regenerated myocardium, wherein the regenerated myocardium exhibits the functional characteristics of adult myocardium following transgene administration.
Dependencies are inferred from the claim text.