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US 8,487,075 B2Granted
Alpha-conotoxin peptides
AssigneeUniversity of Utah Research Foundation
InventorsMaren Watkins, Baldomero M. Olivera, David R. Hillyard, J. Michael McIntosh, Robert M. Jones
Life of this patent
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Abstract
The invention relates to relatively short peptides (termed α-conotoxins herein), about 10-30 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
Claims4
A substantially pure α-conotoxin peptide having the amino acid sequence of:
- Xaa1-Cys-Cys-Thr-Asn-Xaa5-Val-Cys-His-Ala-Xaal-His-Gln-Xaa1-Leu-Cys-Ala-Arg-Arg-Arg (SEQ ID NO:
- 170);
- wherein Xaa1 is Glu or 7-carboxy-Glu (Gla);
- and Xaa5 is Pro or hydroxy-Pro;
- and the C-terminus contains a carboxyl or amide group.
2 more elements
Dependencies are inferred from the claim text.