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US 8,487,000 B2Granted
Compound for the treatment of metabolic disorders
AssigneeWellstat Therapertics Corporation
InventorsShalini Sharma, Reid W. von Borstel
Life of this patent
Estimating the term…
Abstract
Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
Claims38
A compound of the formula:
- wherein
- n is 1 or 2;
- q is 0 or 1;
- t is 0 or 1;
- R5 is alkyl having from 1 to 3 carbon atoms;
- m is 1;
- X is —CH2— and R1 is ethyl, and
- A is phenyl, substituted by 1 or 2 groups selected from:
- fluoro, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy;
- or
- m is 0 or 1,
- X is —CH2CH2— and R1 is hydrogen or alkyl having from 1 to 7 carbon atoms, and
- A is phenyl, substituted by 1 or 2 groups selected from:
- halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy,
- or when R1 is hydrogen, a pharmaceutically acceptable salt of the compound;
- or
- m is 0 or 1,
- X is —CH2CH(NHAc)— and R1 is hydrogen or alkyl having from 1 to 7 carbon atoms, and
- A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from:
- halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy,
- or when R1 is hydrogen, a pharmaceutically acceptable salt of the compound.
18 more elements
A compound having the formula:
- wherein
- n is 1 or 2;
- m is 0 or 1;
- q is 0 or 1;
- t is 0 or 1;
- R5 is alkyl having from 1 to 3 carbon atoms;
- and
- X is —CH2— and R1 is ethyl, and
- one of R2 and R3 is selected from fluoro, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy, and the other is selected from hydrogen, halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy;
- or
- X is —CH2CH2— and R1 is hydrogen or alkyl having from 1 to 7 carbon atoms, and
- one of R2 and R3 is selected from hydrogen, halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy, and the other is selected from halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy,
- or when R1 is hydrogen, a pharmaceutically acceptable salt of the compound;
- or
- X is —CH2CH(NHAc)— and R1 is hydrogen or alkyl having from 1 to 7 carbon atoms, and
- R2 and R3 are each independently selected from hydrogen, halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy,
- or when R1 is hydrogen, a pharmaceutically acceptable salt of the compound.
14 more elements
Dependencies are inferred from the claim text.