Compositions and methods for the diagnosis and treatment of inflammatory disorders and fibrotic disease
AssigneeBoard of Regents of the University of Nebraska
InventorsStephen I. Rennard, Tadashi Sato, Xiang-der Liu, Olaf Holz, Helgo Magnussen
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Abstract
Compositions and methods are disclosed for the treatment and diagnosis of inflammatory diseases and disorders, including pulmonary diseases and fibrotic disorders, including COPD.
Claims12
A method for reducing protein production from a COX-2 mRNA molecule in a lung fibroblast comprising administering an effective amount of miR-146a or a mimic of miR-146a to said fibroblast, said miR-146a or mimic hybridizing to a 3′ end of said COX-2 mRNA, thereby inhibiting COX-2 protein production from said mRNA in a pharmaceutically acceptable carrier, said miR-146a or a mimic of miR-146a being administered via a route selected from the group consisting of inhalation, or intranasal administration.
Dependencies are inferred from the claim text.