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US 8,486,720 B2Granted
Arrays of magnetic particles
AssigneeBioArray Solutions, Ltd.
InventorsSukanta Banerjee, Michael Seul, Alice X. Li
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Abstract
The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful for performing multiplexed (parallel) assays for qualitative and/or quantitative analysis of binding interactions of a number of analyte molecules in a sample.
Claims5
A method of forming an array, comprising:
- providing a plurality of magnetic particles comprising at least two different particle populations, each bearing a different binding agent and being distinguishable by an optically differentiable code associated therewith, suspended in a fluid;
- contacting the magnetic particles with analytes in solution under conditions permitting the binding agents to bind to analytes in an analyte-specific manner;
- assembling the magnetic particles, following said contacting and binding to analytes, in a planar array on one or more chips using a magnetic field;
- and then forming a gel film on the surface of the chips and immobilizing the magnetic particles on the chips by embedding them in the gel film.
1 more element
Dependencies are inferred from the claim text.