Method for the in vitro diagnosis of stroke
AssigneeBio-Rad Innovations
InventorsCatherine Larue, Johann Guegan, Isabelle Giuliani
Life of this patent
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Abstract
A method for the in vitro diagnosis of stroke and transient ischemic attack (TIA) in an individual, including the following steps: (a) measuring the level of proBNP(1-108), or of fragments of proBNP(1-108) including a RAPRSP sequence (SEQ ID NO: 1), in a biological sample of the individual; (b) measuring the level of nucleoside diphosphate kinase A (NDKA) in a biological sample of the individual; (c) comparing the level of proBNP(1-108), or of fragments of proBNP(1-108), and the level of NDKA, with one or several cut-off values; and (d) determining therefrom whether a stroke or a TIA has occurred in the individual.
Claims14
A method for the in vitro diagnosis of stroke and transient ischemic attack (TIA) in an individual, comprising the following steps:
- (a) measuring the level of proBNP(1-108), or of fragments of proBNP(1-108) comprising a RAPRSP sequence (SEQ ID NO:
- 1), in a biological sample of the individual using an immunoassay, wherein the immunoassay comprises an antibody targeting an epitope which comprises the RAPRSP sequence (SEQ ID NO:
- 1);
- (b) measuring the level of nucleoside diphosphate kinase A (NDKA) in a biological sample of the individual;
- (c) comparing the level of proBNP(1-108), or of fragments of proBNP(1-108), and the level of NDKA, with one or several cut-off values;
- and
- (d) determining therefrom whether a stroke or a TIA has occurred in the individual.
A kit for diagnosing stroke or TIA, comprising:
- at least one antibody suitable for detecting proBNP(1-108), or of fragment of proBNP(1-108) which comprise a RAPRSP sequence (SEQ ID NO:
- 1);
- and
- at least one antibody suitable for detecting NDKA.
Dependencies are inferred from the claim text.