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US 8,486,418 B2Granted
Recombinant avian paramyxovirus vaccine and method for making and using thereof
AssigneesMerial Limited, University of Georgia Research Foundation, Inc.
InventorsMichel Bublot, Teshome Mebatsion, Joyce Pritchard, Egburt Mundt
Life of this patent
Estimating the term…
Abstract
The present invention encompasses engineered APMV compositions or vaccines. The vaccine or composition may be a recombinant APMV composition or vaccine. The present invention encompasses methods for modifying the genome of APMV to produce recombinant APMV; modified APMV prepared by such methods; DNA and protein sequences; and methods for infecting cells and host animals with such recombinant APMV.
Claims32
An isolated APMV-8 virus comprising a polynucleotide selected from the group consisting of:
- a) a polynucleotide having the sequence as set forth in SEQ ID NO:1 or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:1;
- b) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:3, a polynucleotide having the sequence as set forth in SEQ ID NO:2, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:2;
- c) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:5, a polynucleotide having the sequence as set forth in SEQ ID NO:4, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:4;
- d) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:7, a polynucleotide having the sequence as set forth in SEQ ID NO:6, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:6;
- e) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:9, a polynucleotide having the sequence as set forth in SEQ ID NO:8, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:8;
- f) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:11, a polynucleotide having the sequence as set forth in SEQ ID NO:10, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:10;
- and
- g) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:13, a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:14, a polynucleotide having the sequence as set forth in SEQ ID NO:12, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:12.
5 more elements
An isolated polynucleotide selected from the group consisting of:
- a) a polynucleotide having the sequence as set forth in SEQ ID NO:1 or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:1;
- b) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:3, a polynucleotide having the sequence as set forth in SEQ ID NO:2, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:2;
- c) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:5, a polynucleotide having the sequence as set forth in SEQ ID NO:4, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:4;
- d) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:7, a polynucleotide having the sequence as set forth in SEQ ID NO:6, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:6;
- e) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:9, a polynucleotide having the sequence as set forth in SEQ ID NO:8, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:8;
- f) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:11, a polynucleotide having the sequence as set forth in SEQ ID NO:10, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:10;
- and
- g) a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:13, a polynucleotide encoding a polypeptide having the sequence as set forth in SEQ ID NO:14, a polynucleotide having the sequence as set forth in SEQ ID NO:12, or a polynucleotide complementary to a polynucleotide having the sequence as set forth in SEQ ID NO:12.
5 more elements
Dependencies are inferred from the claim text.