Back to results
US 8,486,399 B2Granted
Methods and compositions for increasing arylsulfatase A activity in the CNS
AssigneeArmaGen Technologies, Inc.
InventorsWilliam M. Pardridge, Ruben J. Boado
Life of this patent
Estimating the term…
Abstract
Provided herein are methods and compositions for treating a subject suffering from a deficiency in arylsulfatase A in the CNS. The methods include systemic administration of a bifunctional fusion antibody comprising an antibody to a human insulin receptor and an arylsulfatase A.
Claims19
A method for treating an arylsulfatase A (ASA) deficiency in the central nervous system of a subject in need thereof, comprising systemically administering to the subject a therapeutically effective dose of a fusion antibody having arylsulfatase A activity, wherein the fusion antibody comprises:
- (a) a fusion protein comprising the amino acid sequences of an immunoglobulin heavy chain and an arylsulfatase A monomer;
- and (b) an immunoglobulin light chain;
- wherein the fusion antibody crosses the blood brain barrier (BBB) and the ASA retains at least 20% of its activity, on a molar basis, compared to its activity as a separate entity.
Dependencies are inferred from the claim text.