Back to results
US 8,486,398 B2Granted
Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds
AssigneeBoehringer Ingelheim International GmbH
InventorsJoanne Van Ryn, John Edward Park, Norbert Hauel, Ulrich Kunz, Tobias Litzenburger, Keith Canada, Sanjaya Singh, Alisa Waterman
Life of this patent
Estimating the term…
Abstract
The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
Claims31
An isolated antibody molecule of capable of binding to and neutralizing the activity of dabigatran, which comprises a heavy chain variable domain with a CDR1 selected from the group consisting of SEQ ID NO:
- 1 and SEQ ID NO:
- 2, a CDR2 selected from the group consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, and SEQ ID NO:
- 8, and a CDR3 selected from the group consisting of SEQ ID NO:
- 9 and SEQ ID NO:
- 10, and a light chain variable domain with a CDR1 selected from the group consisting of SEQ ID NO:
- 11, SEQ ID NO:
- 12, and SEQ ID NO:
- 13, a CDR2 of SEQ ID NO:
- 14, and a CDR3 of SEQ ID NO:
- 15.
12 more elements
Dependencies are inferred from the claim text.