Compositions and methods for treating or preventing oxalate-related disease
AssigneesOxthera, Inc., The Milton J. Allison Revocable Trust
InventorsHarmeet Sidhu, Milton J. Allison
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Abstract
The present invention comprises methods and compositions for the reduction of oxalate in humans, animals and plants. For example, the invention provides methods and compositions for the delivery of one ore more oxalate-reducing enzymes to the intestinal tracts of persons and animals. The methods and compositions can be used in treating and preventing oxalate-related conditions.
Claims11
A method for reducing an oxalate concentration in a human or animal, comprising, administering to a human or animal an effective amount of freeze-dried viable bacterial cells of Oxalobacter formigenes or oxalate-reducing enzymes, admixed with at least one cryopreservative agent, wherein the amount effective in reducing a portion of the oxalate present from dietary sources or from endogenous sources is from about 107 to about 1012 colony forming units of Oxalobacter formigenes or from about 5 to about 5,000 units of oxalate-reducing enzymes, and wherein the freeze-dried Oxalobacter formigenes cells or oxalate-reducing enzymes are enteric coated for delivery to the small intestine of the human or animal.
A method for treating a human or animal having increased oxalate comprising, administering to said a human or animal an effective amount of freeze-dried viable bacterial cells of Oxalobacter formigenes or oxalate-reducing enzymes, admixed with at least one cryopreservative agent, and reducing, in the gastrointestinal tract, a portion of the oxalate present from dietary sources or from endogenous sources in the human or animal, wherein the amount effective in reducing a portion of the oxalate present from dietary sources or from endogenous sources is from about 107 to about 1012 colony forming units of Oxalobacter formigenes or from about 5 to about 5,000 units of oxalate-reducing enzymes, and wherein the freeze-dried Oxalobacter formigenes cells or oxalate-reducing enzymes are enteric coated for delivery to the small intestine of the human or animal.
Dependencies are inferred from the claim text.