# US 8,481,054 B2 · Pneumococcal serotypes

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- Number: US 8,481,054 B2
- Document ID: US8481054B2
- Status: Granted
- Kind: B2
- Application number: 12/097,815
- Filed: 2006-12-28
- Published: 2010-06-10
- Granted: 2013-07-09
- Earliest claimed: 2005-12-28
- Assignees: The UAB Foundation; Fundacao Oswald Cruz; Instituto Adolfo Lutz
- Applicants: Moon H. Nahm; Jisheng Lin; Angela P. Brandao; Maria Cristina Brandileone
- Inventors: Moon H. Nahm; Jisheng Lin; Angela P. Brandao; Maria Cristina Brandileone
- Web page: https://patentgrep.com/patent/US8481054B2

## CPC

- C12Q 1/689: for bacteria
- A61P 11/00: Drugs for disorders of the respiratory system
- A61P 31/04: Antibacterial agents
- C08B 37/0003: {General processes for their isolation or fractionation, e.g. purification or extraction from biomass}
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C08B: POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6C, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}. This new serotype may be included in pneumococcal vaccines.

## Claims

### Claim 1

A composition comprising a purified polysaccharide comprising the repeating unit {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}.

### Claim 2 (depends on 1)

The composition of claim 1, wherein said polysaccharide is conjugated to a carrier.

### Claim 3 (depends on 2)

The composition of claim 2, wherein the carrier is a protein.

### Claim 4 (depends on 2)

The composition of claim 2, wherein the carrier is a bead.

### Claim 5 (depends on 1)

The composition of claim 1, wherein the polysaccharide is produced by a bacterium expressing the capsule gene locus having the nucleotide sequence of FIG. 17 (SEQ ID NO:43).

### Claim 6 (depends on 1)

The composition of claim 1, wherein the polysaccharide is produced by an isolated Streptococcus pneumoniae 6C, wherein said Streptococcus pneumoniae 6C has a capsular polysaccharide having the repeating unit {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→3) ribitol (5→phosphate}.