Electrical stimulation of cell and tissue growth with two-and three-dimensionally patterned electrodes
AssigneesThe Ohio State University, The Regents of the University of Michigan
InventorsArthur J. Epstein, Stephen E. Feinberg, Derek J. Hansford, Yanyin Yang
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Abstract
The present invention is generally directed to a method for regulating cellular and tissue physiology, a device for practicing the method, and a process for fabricating the device. In general the process comprises the steps of providing at least one patterned electrode, providing a least one cell, placing the at least one electrode in electrical communication with the at least one cell, and applying a voltage to the electrode thereby delivering an effective amount of a patterned electric field or current thus regulating the physiology and/or growth of the at least one cell.
Claims38
A method for regulating cellular and tissue physiology comprising the steps of:
- providing at least one patterned bioabsorbable electrode;
- the bioabsorbable electrode comprising a self-doped sulfonated polyanaline wherein a SO3H dopant is covalently tethered to the polyanaline;
- providing at least one cell;
- placing the at least one patterned bioabsorbable electrode in electrical communication with the at least one cell;
- and
- applying a voltage to the patterned bioabsorbable electrode thereby delivering an effective amount of a patterned electric field or current to the at least one cell, whereby the patterned electric field regulates the physiology or growth of the cell.
A device for regulating cellular and tissue physiology comprising:
- at least one patterned bioabsorbable electrode;
- the bioabsorbable electrode comprising a self-doped sulfonated polyanaline wherein a SO3H dopant is covalently tethered to the polyanaline, the bioabsorbable electrode being capable of delivering an effective amount of a patterned electric field or current to a locus where dosing is indicated.
A process for fabricating a patterned bioabsorbable electrode for regulating cellular and tissue physiology comprising the steps of:
- providing a nonconductive substrate;
- providing a bioabsorbable conductive material comprised of a self-doped sulfonated polyanaline wherein a SO3H dopant is covalently tethered to the polyanaline;
- and
- applying the bioabsorbable conductive material to the substrate in a manner that forms a patterned conductive bioabsorbable film adhering to the substrate.
Dependencies are inferred from the claim text.