Back to results
US 8,476,455 B2Granted
1-N-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them
AssigneeLaboratoire Theramex
InventorsJean Lafay, Benoit Rondot, Paule Bonnet, Thierry Clerc, Jacqueline Shields, Igor Duc, Eric Duranti, Francois Puccio, Christian Blot, Philippe Maillos
Life of this patent
Estimating the term…
Abstract
The invention relates to the compounds of formula (I): in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds.
Claims6
An imidazole compound of formula (I):
- and acid addition salts and stereoisomeric forms thereof, wherein:
- R1 and R2 are each independently hydrogen, a (C1-C6)alkyl;
- Q is selected from the group consisting of C(O), SO2, CONH, C(O)(CH2)n, (CH2)n(O) and (CH2)n where n is 0, 1 or 2;
- Z is the group:
- one of R3 and R8 is cyano and the other is OSO2NR10R11;
- R4 is hydrogen and R9 is hydrogen, hydroxy, cyano, halogen nitro, (C1-C6)alkyl, (C1-C6)alkoxy, trifluoromethyl, acyl, NR10R11, OSO2NR10R11, NR12SO2NR10R11, or CO2R10 group;
- R10, R11 and R12 are each independently hydrogen or a (C1-C6)alkyl;
- and p is 1.
5 more elements
An imidazole compound selected from the group consisting of:
- Sulfamic acid 4-[N-(4-cyanophenylmethyl)-N-(1H-imidazol-1yl)amino]phenyl ester,
- Sulfamic acid 4-{[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)amino]methyl}phenyl ester,
- Sulfamic acid 2-chloro-4-{[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)amino]methyl}phenyl ester,
- Sulfamic acid 2-bromo-4-{[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)amino]methyl}phenyl ester hydrochloride,
- Sulfamic acid 2-methoxy-4-{[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)amino]methyl}phenyl ester,
- Sulfamic acid 2,3,5,6-tetrafluoro-4-{[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)amino]methyl}phenyl ester,
- 4-[N-[(2,2-dioxido-1,2,3-benzoxathiazin-6-yl)methyl]-N-(1H-imidazol-1-yl)amino]benzoitrile,
- Sulfamic acid 4-{[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)amino]sulfonyl}phenyl ester hydrochloride,
- Sulfamic acid 4-{2-[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)amino]ethoxy}phenyl ester,
- Sulfamic acid 4-{[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)-carbamoyl]-methyl}phenyl ester,
- Sulfamic acid 4-{[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)amino]-3-oxopropyl}phenyl ester, and
- Sulfamic acid 3-(aminosulfonyl)amino-4-{[N-(4-cyanophenyl)-N-(1H-imidazol-1yl)amino]methyl}phenyl ester.
9 more elements
Dependencies are inferred from the claim text.