Process for the preparation of dimiracetam
AssigneeNeurotune AG
InventorsCarlo Farina, Jacopo Roletto, Stefano Gobbato
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Abstract
The invention relates to a method of manufacture of dimiracetam (2,5-dioxohexahydro-1 H-pyrrolo[1,2-a]imidazole), characterized in that a 4-oxo-butanoic acid ester is condensed with glycinamide in a one-pot reaction with a controlled pH. The reaction may be performed in aqueous solution or in an anhydrous lower alcohol solution.
Claims14
A method of manufacturing dimiracetam of formula 1, characterized in that a 4-oxo-butanoic acid ester of formula (I), wherein R is lower alkyl, is condensed with glycinamide of formula (II) or an acid addition salt thereof in a one-pot reaction with a controlled pH wherein the pH is kept within the range of pH 5.5 to 7.5
Dependencies are inferred from the claim text.