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US 8,476,449 B2Granted
Radioactive iodine labeled organic compound or salt thereof
AssigneesNihon Medi-Physics Co., Ltd., Kyoto University
InventorsHideo Saji, Masahiro Ono, Ikuya Seki
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Abstract
The present invention is a compound represented by the following formula (1) or a salt thereof. Furthermore, the present invention is an imaging agent used for imaging a tau protein, the imaging agent containing a compound represented by the formula (1) below or a salt thereof. In the formula (1), R3 is a radioactive iodine.
Claims11
A compound represented by the following formula (1) or a salt thereof,
- wherein, in the formula (1), R1 is a sulfur atom or a nitrogen atom, R2 is a substituent represented by the following formula (2),
- or the following formula (3),
- and R3 is a radioactive iodine.
A radioactive iodine labeling precursor comprising a compound represented by the following formula (4) or a salt thereof,
- wherein, in the formula (4), R1 is a sulfur atom or a nitrogen atom, R2 is a substituent represented by the following formula (2),
- or the following formula (3),
- and R4 is a trialkylstannyl substituent with alkyl chains having a length of 1 to 4 carbon atoms, a trialkylammonium substituent with alkyl chains having a length of 1 to 4 carbon atoms, or a triphenylstannyl substituent.
Dependencies are inferred from the claim text.