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US 8,476,439 B2Granted
Pyridine classical cannabinoid compounds and related methods of use
AssigneeUniversity of Tennessee Research Foundation
InventorsBob M. Moore, II, Steven Gurley, Suni Mustafa
Life of this patent
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Abstract
Disclosed are compounds of the formula I: wherein R1, R2, V, W, X, Y and Z can be as defined herein. The compounds can be used in the treatment of disorders mediated by the cannabinoid receptors.
Claims8
A compound of the formula
- wherein:
- ----- represents an optional double bond wherein the ring that optionally contains it is selected from hexahydro, 6a,10a-dehydro, 8,9-dehydro, and 9,10-dehydro;
- Y is selected from CH2, CH(CH3), CH(OH), C(CH3)(OH), C(CH3)2, C(—U(CH2),U—) and C(O);
- n is an integer ≧1;
- U is CH2;
- Z is selected from H, substituted and unsubstituted alkyl,
- and
- cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl, wherein each alkyl portion is optionally substituted up to three tunes and the ring portion of each is optionally substituted with one, two, three, four or five substituents;
- and
- R1 is selected from H and substituted and unsubstituted alkyl.
7 more elements
Dependencies are inferred from the claim text.