Back to results
US 8,476,438 B2Granted
Process for production of camptothecin derivative
AssigneeKabushiki Kaisha Yakult Honsha
InventorsSeigo Sawada, Takashi Yaegashi
Life of this patent
Estimating the term…
Abstract
Disclosed is a process for production of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin from a camptothecin composition containing 18,19-dehydrocamptothecin without producing any vinyl form of the compound. The process is characterized by catalytically reducing at least one compound selected from a compound (1) and others in the process of producing a compound (5) from a composition containing the compound (1).
Claims6
A method for preparing 7-ethyl-10[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin comprising:
- treating a composition comprising 7-ethyl-10[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin and a compound represented by formula (5):
- with a catalyst and hydrogen or a formic acid or its salt as a hydrogen source, such that compound (5) is catalytically reduced to form 7-ethyl-10[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin, and compound (5) is not detectable under standard HPLC conditions following catalytic reduction.
Dependencies are inferred from the claim text.