Tri-, tetra-substituted-3-aminopyrrolidine derivative
AssigneeDaiichi Sankyo Company, Limited
InventorsHisashi Takahashi, Hiroaki Inagaki, Satoshi Komoriya, Makoto Takemura, Rie Miyauchi
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Abstract
An intermediate for production of a quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria.
Claims12
A tetra-substituted 3-aminopyrrolidinyl compound or a salt thereof which is substituted at position 3 and 4 having the formula:
- wherein
- R11 and R21, each indepentyl represents hydrogen atom or a protective group of amino group;
- R3 represents an alkyl group containing 1 to 6 carbon atoms, which being optionally substituted with halogen atom;
- R4 and R5 together represent a 3-membered cyclic structure including the carbon atom shared by R4 and R5 to form a spirocyclic structure with the pyrrolidine ring;
- R6 and R7, each represents hydrogen atom.
A tetra-substituted 3-aminopyrrolidinyl compound or a salt thereof which is substituted at position 3 and 4 having the formula:
- wherein
- R11 and R21, each indepentyl represents hydrogen atom or a protective group of amino group;
- R3 represents an alkyl group containing 1 to 6 carbon atoms, which being optionally substituted with halogen atom;
- R4 and R5 together represent a 3-membered cyclic structure including the carbon atom shared by R4 and R5 to form a spirocyclic structure with the pyrrolidine ring;
- R6 and R7, each represents hydrogen atom.
5-Benzyl-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane or a salt thereof.
(+)- or (−)-5-Benzyl-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane or a salt thereof.
7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane or a salt thereof.
(+)- or (−)-7-(tert-butoxycarbonylamino)-7-methyl-5-azaspiro[2.4]heptane or a salt thereof.
Dependencies are inferred from the claim text.