Preparation of methionine or selenomethionine from homoserine via a carbamate intermediate
AssigneeNovus International, Inc.
InventorsStephen J. Lorbert, Kevin A. Trankler, Richard Vonder Embse, Dayna L. Turner, Tracy Rode, James C. Peterson
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Abstract
Provided herein are processes for the production of methionine or selenomethionine from homoserine. In particular, the processes proceed via the production of carbamate intermediates.
Claims28
A process for preparing a compound comprising Formula (III) or a pharmaceutically acceptable salt thereof, the process comprising:
- a. contacting a compound comprising Formula (I) with a carbonyl donor, wherein the carbonyl donor is chosen from a urea, a urea derivative, a cyclic carbonate, a dialkyl carbonate, a diaryl carbonate, an alkyl carbamate, an aryl carbamate, and a halocarbonyl to form a compound comprising Formula (II);
- and
- b. contacting the compound comprising Formula (II) with a compound comprising MeZ to form the compound comprising Formula (III) or the pharmaceutically acceptable salt thereof:
- wherein:
- Me is methyl;
- and
- Z is sulfur or selenium.
A process for preparing a compound comprising Formula (III) or a pharmaceutically acceptable salt thereof, the process comprising contacting a compound comprising Formula (II) with a compound comprising MeZ to form the compound comprising Formula (III) or the pharmaceutically acceptable salt thereof:
- wherein:
- Me is methyl;
- and
- Z is sulfur or selenium.
Dependencies are inferred from the claim text.