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AssigneesDeutsches Krebsforschungszentrum, Ruprecht-Karls-UniversitäT Heidelberg
InventorsOliver Mueller, Hugo Katus, Karl Varadi, Jürgen Kleinschmidt
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The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.
A DNA polynucleotide encoding an AAV9 capsid polypeptide comprising an inserted peptide as shown in SEQ ID Nos. 1 or 6, wherein the insertion site of the peptide corresponds to amino acid 591 of the AAV9 capsid polypeptide.
Dependencies are inferred from the claim text.