Back to results
US 8,476,413 B2Granted
Sulfanyl-tetrahydropyran-based compounds and methods of their use
AssigneeLexicon Pharmaceuticals, Inc.
InventorsBryce Alden Harrison, Spencer David Kimball, Ross Mabon, David Brent Rawlins
Life of this patent
Estimating the term…
Abstract
Sulfanyl-tetrahydropyran-based compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment of diseases and disorders such as diabetes and obesity are disclosed.
Claims31
A compound of the formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- A is optionally substituted aryl, cycloalkyl, or heterocycle;
- B is optionally substituted aryl, cycloalkyl, or heterocycle;
- Y is O, S, SO, SO2, NR4, (C(R5)2)p, (C(R5)2)q—C(O)—(C(R5)2)q, (C(R5)2)q—C(O)O—(C(R5)2)q, (C(R5)2)q—OC(O)—(C(R5)2)q, (C(R5)2)q—C(O)NR4—(C(R5)2)q, (C(R5)2)q—NR4C(O)—(C(R5)2)q, or (C(R5)2)q—NR4C(O)NR4—(C(R5)2)q;
- R1A is independently hydrogen or optionally substituted alkyl, aryl or heterocycle;
- R2 is fluoro or OR2A;
- each of R2A, R2B, and R2C is independently hydrogen, optionally substituted alkyl, C(O)alkyl, C(O)aryl, or aryl;
- each R4 is independently hydrogen or optionally substituted alkyl;
- each R5 is independently hydrogen, hydroxyl, halogen, amino, cyano, OR5A, SR5A, or optionally substituted alkyl;
- each R5A is independently optionally substituted alkyl;
- p is 0-3;
- and
- each q is independently 0-2.
10 more elements
A compound of the formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1A is independently hydrogen or optionally substituted alkyl, aryl or heterocycle;
- R2 is fluoro or OR2A;
- each of R2A, R2B, and R2C is independently hydrogen, optionally substituted alkyl, C(O)alkyl, C(O)aryl, or aryl;
- each R6 is independently hydrogen, hydroxyl, halogen, amino, cyano, nitro, C≡CR6A, OR6A, SR6A, SOR6A, SO2R6A, C(O)R6A, CO2R6A, CO2H, CON(R6A)(R6A), CONH(R6A), CONH2, NHC(O)R6A, NHSO2R6A, or optionally substituted alkyl, aryl or heterocycle;
- each R6A is independently optionally substituted alkyl, aryl or heterocycle;
- each R7 is independently hydrogen, hydroxyl, halogen, amino, cyano, nitro, C≡CR7A, OR7A, SR7A, SOR7A, SO2R7A, C(O)R7A, CO2R7A, CO2H, CON(R7A)(R7A), CONH(R7A), CONH2, NHC(O)R7A, NHSO2R7A, or optionally substituted alkyl, aryl or heterocycle;
- each R7A is independently optionally substituted alkyl, aryl or heterocycle;
- m is 1-3;
- and
- n is 1-3.
8 more elements
A compound of the formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1A is independently hydrogen or optionally substituted alkyl, aryl or heterocycle;
- each R6 is independently hydrogen, hydroxyl, halogen, amino, cyano, nitro, C≡CR6A, OR6A, SR6A, SOR6A, SO2R6A, C(O)R6A, CO2R6A, CO2H, CON(R6A)(R6A), CONH(R6A), CONH2, NHC(O)R6A, NHSO2R6A, or optionally substituted alkyl, aryl or heterocycle;
- each R6A is independently optionally substituted alkyl, aryl or heterocycle;
- each R7 is independently hydrogen, hydroxyl, halogen, amino, cyano, nitro, C≡CR7A, OR7A, SR7A, SOR7A, SO2R7A, C(O)R7A, CO2R7A, CO2H, CON(R7A)(R7A), CONH(R7A), CONH2, NHC(O)R7A, NHSO2R7A, or optionally substituted alkyl, aryl or heterocycle;
- each R7A is independently optionally substituted alkyl, aryl or heterocycle;
- m is 1-3;
- and
- n is 1-3.
6 more elements
Dependencies are inferred from the claim text.