Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsXinhui Wang, Soldano Ferrone
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Abstract
Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind HMW-MAA. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed. The antibodies can be used to detect HMW-MAA in a sample. Methods of diagnosing cancer, or confirming a diagnosis of cancer, are disclosed herein that utilize these antibodies. Methods of treating a subject with cancer are also disclosed.
Claims12
An isolated human monoclonal antibody or antigen-binding fragment thereof, wherein the heavy chain variable region of the antibody or antigen-binding fragment thereof comprises amino acids 27-38 of SEQ ID NO:
- 5, amino acids 56-65 of SEQ ID NO:
- 5, and amino acids 105-115 of SEQ ID NO:
- 5;
- and the light chain variable region of the antibody or antigen-binding fragment thereof comprises amino acids 27-38 of SEQ ID NO:
- 6, amino acids 56-65 of SEQ ID NO:
- 6, and amino acids 105-110 of SEQ ID NO:
- 6, and wherein the antibody specifically binds HMW-MAA.
Dependencies are inferred from the claim text.