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AssigneeAlize Pharma SAS
InventorsMaria Brizzi, Giampiero Muccioli, Ezio Ghigo
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The present invention relates to a method for treating a cardiovascular disease, for increasing the number of circulating angiogenic cells (CAC) and/or improving the function of CAC and a method for improving vascular remodeling and/or neovascularisation. The method comprises administering to the subject a therapeutically effective amount of unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1; and to pharmaceutical compositions comprising unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1.
A method for treatment of ischemia in a subject, comprising administering to the subject a therapeutically effective amount of (i) a polypeptide consisting of a fragment of unacylated ghrelin as set forth in SEQ ID NO:
Dependencies are inferred from the claim text.