Neuregulin variants and methods of screening and using thereof
AssigneeZensun (Shanghai) Science & Technology, Co., Ltd.
InventorMingdong Zhou
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Abstract
The present invention provides polypeptide variants of neuregulin-1β (NRG-1β) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4. The invention also provides methods of screening and producing polypeptide variants of NRG-1β and methods of using polypeptide variants of NRG-1β for treating diseases.
Claims84
An isolated polypeptide variant of neuregulin-1β comprising amino acid sequence shown in SEQ ID NO:1, wherein the polypeptide variant comprises two different amino acids than that in SEQ ID NO:1, wherein the polypeptide variant has an enhanced binding affinity to ErbB4 compared to polypeptide of SEQ ID NO:1, and wherein
- at residue 47 the first of said two different amino acids is A, C, D, E, F, G, H, I, K, L, M, P, Q, R, S, T, V, W, or Y, and
- at residue 8 the second of said two different amino acids is A.
A kit comprising the polypeptide variant of 1.
A kit comprising the polypeptide variant of 62.
Dependencies are inferred from the claim text.