Hyperbranched polymers and their applications
AssigneeAgency for Science, Technology and Research
InventorsYe Liu, Decheng Wu, Chaobin He
Life of this patent
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Abstract
The present invention provides a branched, a dendritic, or a hyperbranched poly(amino ester) having a polymer backbone comprising a plurality of branches, wherein the polymer backbone has at least one secondary and at least one tertiary amine linkage. Branched poly(amino ester)s are prepared via a Michael addition reaction of a tris(acrylate ester)monomer with a diamine monomer. In one aspect, the diamine monomer has a primary amino group and a secondary amino group. The poly(amino ester) compounds can be end-capped by reacting with a suitable agent. The present invention also provides applications including, but are not limited to, the delivery of bioactive agents, such as drugs, DNA or RNA; or biocompatible imaging.
Claims9
A branched poly(amino ester) compound having the formula:
- wherein
- x is an integer between 1 and about 10,000;
- each of R1, R2 and R3 is independently selected from the group consisting of hydrogen and hydrocarbyl;
- each of R4, R5, R6, R7, R8 and R9 is independently selected from the group consisting of hydrogen and hydrocarbyl and alkyl;
- each of L1 and L2 is N(—R13—)(—R14—)Z, wherein each of R13 and R14 is bonded to N and Z to form a cyclic structure, and wherein each of R10, R11, R13 and R14 is independently an optionally substituted C1-30alkylene;
- and each Z is independently selected from the group consisting of N, and CH, with the proviso that R1, R2, R3, R4, R5, R6, R7, R8, R9 and R12 cannot have a primary amino group, a secondary amino group, or a carbon-carbon double bond conjugated to a carbonyl group;
- Y1 is selected from the group consisting of (alkylene)3CRc, wherein each Rc is independently selected from the group consisting of alkyl and aryl;
- A is selected from the group consisting of optionally substituted piperazinyl, optionally substituted piperidinyl, optionally substituted azetidinyl, optionally substituted pyrrolidinyl, N-methyl piperazinyl, N-ethyl piperazinyl, and 1-methyl-4-methylamino-piperidinyl, and benzyl-1-piperazinyl carboxylate;
- and
- each of B1 and B2 is independently selected from the group consisting of H and hydrocarbyl.
Dependencies are inferred from the claim text.