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US 8,476,335 B2Granted
Method of manufacturing monolithic stationary phase and monolithic stationary phase produced thereby
AssigneeChung Yuan Christian University
InventorsHsi-Ya Huang, Yung-Han Shih, Chao-Hsiang Hsu, Wan-Ling Liu, Singco Brenda
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Abstract
The present invention relates to a method of manufacturing a polymer-based monolithic stationary phase in an ionic liquid reaction medium via microwave-assisted vinylization and polymerization. The invention is time-effective and environmental friendly for not using volatile organic compounds.
Claims15
A method of manufacturing a monolithic stationary phase comprising the steps of:
- (a) providing a substrate having a working surface;
- (b) vinylizing the working surface in the presence of an ionic liquid as a solvent by reacting the working surface with an alkoxy silane compound that is reactive to the working surface to create a Si—O—Si linkage and has a pendant vinyl functionality and applying microwave radiation at a power level sufficient for the vinylization, thereby obtaining a vinylized working surface having reactive vinyl groups thereon;
- and
- (c) initiating an in situ free radical polymerization of a polymerizable mixture containing a vinyl monomer in the presence of an ionic liquid as a solvent to result in a polymer-based monolithic stationary phase grafted to the vinylized working surface.
1 more element
Dependencies are inferred from the claim text.