Methods of treating ear infections
Assignee3M Innovative Properties Company
InventorsMatthew T. Scholz, Danli Wang, Jeffrey F. Andrews
Life of this patent
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Abstract
Methods of treating and/or preventing otitis media in a subject are provided. Methods of treating and/or preventing otitis externa are also provided.
Claims13
A method of treating otitis media in a subject, the method comprising delivering an antimicrobial composition across the tympanic membrane and/or tympanic membrane surrounding tissue to the middle ear by contacting the tympanic membrane, and/or tympanic membrane surrounding tissue with the antimicrobial composition comprising:
- an effective amount of an antimicrobial lipid component having a solubility in water of no greater than 1.0 gram per 100 grams deionized water and comprising an antiseptic selected from the group of a (C7-C14)saturated fatty acid monoester of glycerol, a (C7-C14)saturated fatty acid monoester of propylene glycol, a (C8-C22)unsaturated fatty acid monoester of glycerol, a (C8-C22)unsaturated fatty acid monoester of propylene glycol, an alkoxylated derivative of any of the foregoing having a free hydroxyl group, and combinations thereof;
- wherein the alkoxylated derivative has less than 5 moles of alkoxide per mole of glycerol or propylene glycol;
- and
- an effective amount of a penetration agent, wherein the penetration agent promotes the diffusion of the antimicrobial component into the middle ear;
- wherein the fatty acid esters or alkoxylate derivatives thereof comprise less than 15 wt-% di- or tri-esters based on the total weight of the antimicrobial lipid component;
- and
- wherein the viscosity of the composition is less than 20 cps at 23° C.
A method of treating otitis media and/or otitis externa in a subject, the method comprising delivering an antimicrobial composition across the tympanic membrane and/or tympanic membrane surrounding tissue to the middle ear by contacting the tympanic membrane, and/or tympanic membrane surrounding tissue with the antimicrobial composition, the composition comprising:
- greater than 2 wt-% and less than 6 wt-% of an antimicrobial lipid component having a solubility in water of no greater than 1.0 gram per 100 grams deionized water and comprising an antiseptic selected from the group of a (C7-C14)saturated fatty acid monoester of gylcerol, a (C7-C14)saturated fatty acid monoester of propylene glycol, a (C8-C22)unsaturated fatty acid monoester of glycerol, a (C8-C22)unsaturated fatty acid monoester of propylene glycol, an alkoxylated derivative of any of the foregoing having a free hydroxyl group, and combinations thereof;
- wherein the alkoxylated derivative has less than 5 moles of alkoxide per mole of glycerol or propylene glycol;
- wherein the viscosity of the composition is less than 20 cps at 23° C.
A method of treating otitis media in a subject, the method comprising delivering an antimicrobial composition across the tympanic membrane and/or tympanic membrane surrounding tissue to the middle ear by contacting the tympanic membrane, and/or tympanic membrane surrounding tissue with the antimicrobial composition comprising:
- an effective amount of an antimicrobial lipid component having a solubility in water of no greater than 1.0 gram per 100 grams deionized water and comprising an antiseptic selected from the group of a (C7-C14)saturated fatty acid monoester of glycerol, a (C7-C14)saturated fatty acid monoester of a propylene glycol, a (C8-C22)unsaturated fatty acid monoester of glycerol, a (C8-C22)unsaturated fatty acid monoester of propylene glycol, an alkoxylated derivative of any of the foregoing having a free hydroxyl group, and combinations thereof;
- wherein the alkoxylated derivative has less than 5 moles of alkoxide per mole of glycerol or propylene glycol;
- and
- an effective amount of a penetration agent, wherein the penetration agent promotes the diffusion of the antimicrobial component into the middle ear;
- wherein the antimicrobial composition is free of antibiotics.
A method of treating otitis media in a subject, the method comprising delivering an antimicrobial composition across the tympanic membrane and/or tympanic membrane surrounding tissue to the middle ear by contacting the tympanic membrane, and/or tympanic membrane surrounding tissue with the antimicrobial composition, the composition comprising
- an effective amount of an antimicrobial lipid component having a solubility in water of no greater than 1.0 gram per 100 grams deionized water and comprising an antiseptic selected from the group of a (C7-C14)saturated fatty monoether of glycerol, a (C7-C14)saturated fatty monoether of propylene glyol, a (C8-C22)unsaturated fatty monoether of glycerol, a (C8-C22)unsaturated fatty monoether of propylene glycol, an alkoxylated derivative of any of the foregoing having a free hydroxyl group, and combinations thereof;
- wherein the alkoxylated derivative has less than 5 moles of alkoxide per mole of l glycerol or propylene glycol.
Dependencies are inferred from the claim text.