Therapeutic agent or prophylactic agent for inflammatory bowel disease comprising amino alcohol derivative as active ingredient
AssigneeKyorin Pharmaceutical Co., Ltd.
InventorsNaoya Yamamuro, Koichi Nakamaru, Tokutarou Yasue
Life of this patent
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Abstract
A novel therapeutic agent or prophylactic agent for an inflammatory bowel disease is provided. An amino alcohol derivative represented by the general formula (1): which is a sphingosine-1-phosphate receptor agonist or a pharmaceutically acceptable salt or hydrate thereof are a therapeutic agent or prophylactic agent for an inflammatory bowel disease comprises.
Claims4
A method of treating an inflammatory bowel disease, the method comprising administering to a patient in need thereof, an effective amount of a (R)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylpentan-1-ol, or a pharmaceutically acceptable salt thereof.
A method of treating an inflammatory bowel disease, the method comprising administering to a patient in need thereof, an effective amount of a (−)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylpentan-1-ol, or a pharmaceutically acceptable salt thereof,
- wherein the (−)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylpentan-1-ol, or a pharmaceutically acceptable salt thereof, is obtained by:
- allowing a compound represented by formula (2) and a compound represented by formula (10) to react with each other in the presence of a base,
- wherein R1 represents a trifluoromethyl group, R2 represents a chlorine atom, A represents a halogen atom, X represents a sulfur atom, and n denotes 3,
- wherein R3 represents a methyl group and R4 represents an alkyl group having 2 carbon atoms,
- subjecting a resultant product to acidolysis,
- protecting a nitrogen atom with a t-butoxycarbonyl group,
- reducing a resultant protected compound, and
- deprotecting the nitrogen atom of a resultant reduced compound.
A method of treating an inflammatory bowel disease, the method comprising administering to a patient in need thereof, an effective amount of a (−)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylpentan-1-ol or a pharmaceutically acceptable salt thereof.
A method of treating an inflammatory bowel disease, the method comprising administering to a patient in need thereof, an effective amount of a (R)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylpentan-1-ol, or a pharmaceutically acceptable salt thereof,
- wherein the (R)-2-amino-5-[2-chloro-4-(3-trifluoromethylphenylthio)phenyl]-2-methylpentan-1-ol, or a pharmaceutically acceptable salt thereof, is obtained by:
- allowing a compound represented by formula (2) and a compound represented by formula (10) to react with each other in the presence of a base,
- wherein R1 represents a trifluoromethyl group, R2 represents a chlorine atom, A represents a halogen atom, X represents a sulfur atom, and n denotes 3,
- wherein R3 represents a methyl group and R4 represents an alkyl group having 2 carbon atoms,
- subjecting a resultant product to acidolysis,
- protecting a nitrogen atom with a t-butoxycarbonyl group,
- reducing a resultant protected compound, and
- deprotecting the nitrogen atom of a resultant reduced compound.
Dependencies are inferred from the claim text.