N-aminopyrrolylmethyltetrahydropyridines as anti-cancer agents
AssigneeFlorida A&M University Board of Trustees
InventorsKinfe Ken Redda, Madhavi Gangapuram
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Abstract
The compounds herein disclosed are N-aminopyrrolylmethyltetrahydropyridine analogs that have modifications on the phenyl rings by introducing groups with various electronic properties. These derivatives of N-aminopyrrolylmethyltetrahydropyridines have been shown to have anti-proliferative activity against cells. In particular, the compounds have been found to be effective in inhibiting the proliferation of cancer cells, such as cancer cells that originated in breast tissue. Additionally, it has been shown that the novel compounds have IC50 values against the breast cancer cells that are 6-10-fold less than the IC50 of tamoxifen.
Claims15
A compound having the structure of formula I:
- wherein:
- X is a carbonyl group or a sulfonyl group;
- and
- R1 is H, an alkyl group, an alkoxy group, or an electronegative group;
- or a salt thereof.
A pharmaceutically acceptable composition comprising a compound having the structure:
- wherein:
- X is a carbonyl group or a sulfonyl group;
- and
- R1 is H, an alkyl group, an alkoxy group, or an electronegative group;
- or a salt thereof;
- and
- a pharmaceutically acceptable carrier.
A method of inhibiting the proliferation of a breast cancer cell comprising contacting a breast cancer cell with an effective amount of a compound having the structure:
- wherein:
- X is a carbonyl group or a sulfonyl group;
- and
- R1 is H, an alkyl group, an alkoxy group, or an electronegative group;
- or a salt thereof or a salt thereof, and a pharmaceutically acceptable carrier, thereby reducing the proliferation rate of the cell compared to the proliferation rate of a cell not in contact with the compound.
Dependencies are inferred from the claim text.