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US 8,476,293 B2Granted
Tricyclic compound and use thereof
AssigneeOno Pharmaceutical Co., Ltd.
InventorsKazuyuki Ohmoto, Masashi Kato, Yoshifumi Kagamiishi, Junichiro Manako
Life of this patent
Estimating the term…
Abstract
The present invention relates to the compound represented by formula (I): (wherein, all the symbols have the same meaning as that of the specification), a salt thereof, a solvate thereof or a prodrug thereof. Since the compound of the present invention has an anti stress action, it is useful for preventive and/or therapeutic agent for a disease caused by stress, especially a digestive system disease caused by stress and is superior to oral absorption.
Claims7
A compound represented by formula (I-B-1-2):
- wherein R201 is selected from (1) methoxy which may have a fluorine atom(s), (2) isopropoxy which may have a fluorine atom(s), and (3) cyclopentyloxy which may have a fluorine atom(s), R202 is selected from (1) fluorine atom, (2) chlorine atom, (3) cyano, (4) methyl, and (5) methoxy which may have a fluorine atom(s), R1 is a hydrogen atom, C1-8 alkyl, C1-8 alkoxy, or halogen atom, tA is 0 or an integer of 1 to 4
- a salt thereof, or an N-oxide thereof;
- wherein (1S)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-fluoro-1,2,3,9-tetrahydrospiro[β-carboline-4,1′-cyclopropane] is excluded.
Dependencies are inferred from the claim text.